• RN486 Collectively these observations demonstrate that FAAH

  2022-09-01

  

  Collectively, these observations demonstrate that FAAH is functionally positioned to modulate the actions of AEA and other NAEs on BLA neurons and anxiety processes mediated by this region. By extension, manipulations that lead to alterations in FAAH activity, such as stress or administration of com

• br Methods br Results br Discussion

  2022-08-31

  

  Methods Results Discussion In the general population BNP has been established as a marker for Ciclopirox failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional risk facto

• Bile acids synthesized in the liver are secreted into

  2022-08-31

  

  Bile acids synthesized in the liver are secreted into the intestinal tract to facilitate the digestion and Zalcitabine receptor of nutrients. Most bile acids are reabsorbed by the ileum and are transported back to the liver via the portal blood circulation. Recently, bile acids have also been consid

• Finally worth of mention are few papers that

  2022-08-31

  

  Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a IWR-1-endo library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series

• Any brain damage including that caused by amyloid triggers a

  2022-08-31

  

  Any Mesoridazine damage, including that caused by β-amyloid, triggers activation of microglia, the resident immune cells of the CNS. These cells cluster around amyloid plaques, in which they extend cytoplasmic processes (Combs, 2009). The significance of this response is controversial, but one poss

• To date no studies have demonstrated

  2022-08-31

  

  To date, no studies have demonstrated any effect of obesity or inflammation on GPR109A expression in adipose tissue. Our findings demonstrate that HFD-induced obesity decreases adipose tissue GPR109A gene expression. Contradictory to our findings in adipose tissue in vivo, Digby et al. report that e

• The global spread and ever increasing incidence of

  2022-08-30

  

  The global spread and ever-increasing incidence of metabolic syndrome over the past few decades has not only categorized it as an ‘epidemic’ but has also dramatically increased the risk of cardiovascular diseases and diabetes. The increase in prevalence of diabetes in the United States alone has bee

• The effects of opioids such as morphine are mediated

  2022-08-30

  

  The effects of opioids such as morphine are mediated through the opioid receptors. Opioid receptors are widely expressed both peripherally and in the CNS (Chen et al., 1993, Evans et al., 1992). The opioid agonist morphine has been shown to amplify the effect of the tubular cell-gp120 interaction on

• br Results and discussion br Conclusion In this study the

  2022-08-30

  

  Results and discussion Conclusion In this study the first binding assays based on a nonlabelled reporter ligand addressing GlyT1 are described. Following the concept of MS Binding Assays recently introduced in our group, binding of the well-known GlyT1 inhibitor Org24598 employed as reporter l

• Although glycine receptors predominate in the brain

  2022-08-29

  

  Although glycine receptors predominate in the brain stem and spinal cord, they are also expressed in higher brain regions such as the nucleus accumbens, frontal cortex, and hippocampus (Jonsson et al., 2012, Jonsson et al., 2009, Molander and Söderpalm, 2005b). A variety of drugs of abuse, including

• br Results and discussion br Conclusion In conclusion

  2022-08-29

  

  Results and discussion Conclusion In conclusion, we designed and synthesized a novel series of thiosemicarbazide-1,2,3-triazole hybrids 10a-o. Further, α-glucosidase inhibitory activity of the synthesized compounds 10a-o was evaluated. The obtained results showed that all the synthesized thios

• So far only few studies

  2022-08-29

  

  So far only few studies report about GAL in the visual system: GAL has been detected in the cornea of rat (Jones and Marfurt, 1998), mouse (Henken and Martin, 1992) and pig (Stone et al., 1988), and in the uvea of rat (Strömberg et al., 1987), pig (Stone et al., 1988) and cat (Grimes et al., 1994),

• Inflammasomes are multimeric protein complexes

  2022-08-29

  

  Inflammasomes are multimeric protein complexes involved in the host defense protecting activity against invading pathogens and in physiological aberrations such as cancer and auto-inflammatory, metabolic, and neurodegenerative diseases. Inflammasomes induce the inflammatory process by triggering the

• Distribution of histamine receptors in the intestines varies

  2022-08-26

  

  Distribution of histamine receptors in the intestines varies among species, but our findings are similar to those previously reported in humans and guinea pigs (Thurmond, 2010, Thurmond, 2015). H1 receptors were located mainly in the gastric mucosa, smooth muscle, and lymphoid tissue, corresponding

• While the binding of HK to VDAC is

  2022-08-26

  

  While the binding of HK1 to VDAC1 is strong and continuous, the binding of HK2 to VDAC1 is much weaker, and alternates between a cytoplasmic and a mitochondrial-bound states (John et al., 2011). This dynamic process is regulated by the metabolic and energetic requirements of the how to find the mola

15475 records 406/1032 page Previous Next First page 上5页 406407408409410 下5页 Last page